Matthew J. Ellis, MB, BChir, BSc., PhD, FRCP

Professor / Director
Baylor College of Medicine

Matthew J. Ellis, MB, BChir, BSc., PhD, FRCP Photo


Professor / Director
Lester and Sue Smith Breast Center - Administrative
Oncology/Medicine and MCB
Baylor College of Medicine
Houston, TX US

McNair Scholar
Baylor College of Medicine
Houston, Texas United States

Associate Director of Precision Medicine
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States


McNair Campus (Clinic)
Lester & Sue Smith Breast Center
7200 Cambridge St 7th Floor
Houston, Texas 77030
United States
(713) 798-1999
Google Maps
BCM-Cullen Building (Office)
Room: BCMC-335
Mail Stop: BCM600
Houston, Texas 77030
United States
Google Maps


  • MD from University of Cambridge
    05/1984 - Cambridge England

    MB., BChir.

  • PhD from University of London
    05/1992 - London United Kingdom

    Molecular Biology

  • Fellowship at Georgetown University Hospital
    06/1994 - Washington, District of Columbia United States

    Medical Oncology

  • Residency at Royal College of Physicians
    06/1988 - London United Kingdom


  • BSc from University of London
    05/1980 - London United Kingdom



  • English


  • Male

Professional Statement

Dr. Matthew James Ellis is a native of the United Kingdom. He completed his medical degree at Queens' College & School of Clinical Medicine at the University of Cambridge in England, postgraduate clinical training at the Royal College of Physicians in London and gained a Ph.D. at the Royal Postgraduate Medical School and Imperial Cancer Research Fund at the University of London. After a medical oncology fellowship at the Lombardi Cancer Center, Georgetown University, Washington DC, he was an Assistant Professor there until moving to Duke University in 2000 and subsequently to Washington University in St Louis where he served as professor of medicine and section head of breast oncology until 2014. Ellis was recently recruited to Baylor College of Medicine to serve as the Director of the Lester and Sue Smith Breast Center and to hold the C. Kent Osborne Chair of Breast Oncology. Both the McNair Foundation and the Cancer Prevention Research Institute of Texas recently awarded him scholarships. He has been instrumental in developing a Genome Atlas and Therapeutic Road Map for estrogen receptor positive breast cancer by applying genomic techniques to samples accrued through a series of neoadjuvant endocrine therapy trials. Most recently, he has found that metastatic breast tumors harbor mutations and translocations in the estrogen receptor gene that render the tumor resistant to therapies used to block estrogen receptor function. He also pioneered research into the clinical relevance of activating mutations in HER2 and in the deployment of patient-derived xenografts for the pharmacological annotation of breast cancer genomes. He is currently Co-Chair of the translational medicine committee for the NRG cooperative group, co-leader for The Cancer Genome Atlas (TCGA) Breast Project and also serves as a Co-PI for the Clinical Proteomic Tumor Analysis Consortium that endeavors to translate TCGA genomic discoveries into protein-based biomarkers with clinical utility. Dr. Ellis has a successful track record in international clinical and translational research, with recent trainees from Brazil, Chile, Poland and Turkey.

Professional Achievements

  • CPRIT Scholar in Cancer Research

  • C. Kent Osborne Endowed Chair
    Baylor College of Medicine

  • Gianni Bonadonna Breast Cancer Award
    06/2015 - American Society of Clinical Oncology

  • Elected Member
    04/2018 - Association of American Physicians

Professional Interests

  • Breast Cancer Oncology

  • Breast Cancer Genomics

  • Metastatic Breast Cancer

  • Clinical Trials

Professional Specialties

  • Breast Oncology