Sandesh C.S. Nagamani, M.B.B.S, M.D.

Associate Professor
Baylor College of Medicine

Sandesh C.S. Nagamani, M.B.B.S, M.D. Photo


Associate Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX US

Director, Division of Clinical Research
Molecular and Human Genetics
Baylor College of Medicine

Associate Professor
Department of Medicine
Baylor College of Medicine

Director, Clinical Translational Core
Intellectual and Developmental Disabilities Research Center (IDDRC)
Baylor College of Medicine


Adult Genetics Clinic (Clinic)
Baylor College of Medicine Medical Center - McNair Campus
7200 Cambridge St.
9th Floor, Suite 9A
Houston, Texas 77030
United States
(713) 798-7764
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  • American Board of Internal Medicine

  • American Board of Medical Genetics and Genomics


  • MBBS from University of Mysore
    01/1999 - Mysore, India

    Medical School

  • Residency at Gandhi Medical College
    01/2003 - Bhopal, India

    Internal Medicine

  • Internship at Fairview Hospital, A Cleveland Clinic Hospital
    06/2006 - Cleveland, Ohio United States
  • Residency at Baylor College Of Medicine
    06/2008 - Houston, Texas United States

    Clinical Genetics

  • Postdoctoral Training at Baylor College Of Medicine
    06/2009 - Houston, Texas United States

    Clinical Genetics

  • Residency at Baylor College Of Medicine
    10/2009 - Houston, Texas United States

    Internal Medicine


  • English
  • Hindi
  • Kannada


  • Male

Professional Statement

My research interests are focused on translational medicine, specifically, evaluating new and potential therapies for various genetic disorders. I am particularly interested in conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in patients with inborn errors of metabolism and skeletal dysplasias. As the Co-PI for the NIH Rare Disease Clinical Research Network's Urea Cycle Disorders Consortium (UCDC), I am actively involved in conducting natural history studies, data-mining projects, and exploratory studies aimed at improving therapies for UCDs. We discovered that some distinct features of UCDs could be a result of perturbations of non-ureagenic functions of urea cycle enzymes. In particular, we have shown that nitric oxide (NO) deficiency in the UCD argininosuccinate lyase deficiency (ASLD) contributes to the phenotype of the disorder. We are now translating these molecular findings into the clinical realm by performing clinical trials to evaluate the effects of NO supplementation on vascular and neurocognitive parameters in ASLD. Another research area of interest is in regards to osteogenesis imperfecta (OI), a heritable form of brittle bone disease. We were the first group to show efficacy of anabolic bone therapy in milder forms of OI. BCM is the primary site for the Brittle Bone Disease Consortium (BBDC) of the NIH RDCRN. I save as a lead investigator for the consortium and am leading a Phase I/II study evaluating the safety and efficacy of TGF inhibition in subjects with severe forms of OI. Clinical Interests As an adult clinical geneticist, I provide clinical care for adult patients with a wide variety of heritable conditions. I serve as the Director of the Clinic for Metabolic and Genetic disorders of bone that caters to adult subjects with OI, heritable disorders of bone, early-onset osteoporosis, and other common forms of metabolic bone diseases. Teaching Activities I am actively involved in the teaching and mentoring of medical students and direct one of the preclinical electives for the Genetics and Genomics Pathway. I also serve as the PI for the Career Enhancement Cores of two consortia of the RDCRN namely, UCDC and the BBDC.

Professional Achievements

  • Adult Genetics Excellence in Education Award
    Department of Molecular and Human Genetics, Baylor College of Medicine

  • Consultant for Endocrinologic and Metabolic Drug Advisory Committee
    11/2013 - Food and Drug Administration, USA

  • Rising Star Award
    05/2015 - Baylor College of Medicine

  • Norton Rose Fulbright Faculty Excellence Award

Professional Specialties

  • Metabolic Bone Disease

  • Genetics